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KMID : 0380620190510010081
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Korean Journal of Food Science and Technology
2019 Volume.51 No. 1 p.81 ~ p.89
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Anti-obesity effect of 3,5-dicaffeoylquinic acid on high-fat diet mouse
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Kang Jin-Yong
Park Seon-Kyeong
Kim Jong-Min
Park Su-Bin
Yoo Seul-Ki
Han Hye-Ju
Kim Dae-Ok
Heo Ho-Jin
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Abstract
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This study was performed to confirm the influence of chlorogenic acid (CGA) and 3,5-dicaffeyolquinic acid (3,5-diCQA) intake on problems caused by high-fat diet. CGA was more effective in suppressing weight gain than 3,5-diCQA. In contrast, 3,5-diCQA was more effective in improving glucose tolerance than CGA. In the biopsy, it was confirmed that CGA inhibited visceral fat and liver fat accumulation. 3,5-diCQA also inhibited visceral fat accumulation, but 3,5-diCQA increased liver fat accumulation. The liver fat accumulation induced oxidative stress, but 3,5-diCQA reduced oxidative damage through its antioxidant activity. The increased liver fat accumulation was because a 3,5-diCQA greatly increased Akt phosphorylation and decreased AMPK phosphorylation in the liver. Consequently, CGA was effective in alleviating the problems caused by high-fat diets, while maintaining normal balance. 3,5-diCQA also showed a positive effect on problems caused by high-fat diets, but it increased liver fat accumulation and thereby had negative consequences.
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KEYWORD
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3,5-dicaffeoylquinic acid, chlorogenic acid, obesity, p-AMPK, p-Akt
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